signal transduction and diabetes
Mishra D and Dey CS: Protein Kinase C attenuates insulin signalling cascade in insulin-sensitive and insulin-resistant Neuro2-a cells. J. Mol. Neurosc. 2019, 69, 470.
Varshney P and Dey CS: Resveratrol regulates neuronal glucose uptake and insulin sensitivity via P21-activated kinase 2 (PAK2). Biochem. Biophys. Res. Comm. 2017, 485, 372.
Choudhary AK and Dey CS: Nuclear corepressor (NCoR) is required to maintain insulin sensitivity in C2C12 myotubes. Cell Biol. Int. 2016, 9999, 1.
Arora A and Dey CS: SIRT2 regulates insulin sensitivity in insulin-resistant neuronal cells. Biochem. Biophys. Res. Comm. 2016, 474, 747.
Varshney P and Dey CS: P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells. Mol. Cell. Endocrinol. 2016, 429, 50.
Arora A and Dey CS: SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells. Biochim. Biophys. Acta - Molecular Basis of Disease 2014,1842,1372.
Patel MI, Gupta A, Dey CS: Potentiation of neuronal insulin signaling and glucose uptake by Resveratrol: an involvement of AMPK. Pharm. Rep. 2011,63, 1162.
Shah AK, Gupta A and Dey CS: AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake. Arch. Biochem. Biophys. 2011, 509: 142.
Gupta, A; Bisht, B and Dey CS: Peripheral insulin-sensitizer drug Metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes Neuropharmacology. 2011, 60, 910.
Gupta A and Dey CS: PTEN and SHIP2 regulates PI3K/ Akt pathway through Focal adhesion kinase. Mol. Cell. Endocrinol. 2009, 309, 55.
Bisht B and Dey CS: Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells. BMC Cell Biology 2008, 9, 48.
Bisht B, Srinivasan K and Dey CS. In vivo inhibition of Focal Adhesion Kinase causes insulin resistance. J. Physiology. 2008, 586, 16, 3825.
Bisht, B, Goel, HL and Dey, CS. Focal Adhesion Kinase regulates insulin resistance in skeletal muscle. Diabetologia. 2007, 50, 1058.
Singh, J, Verma, NK, Kansagra Sejal M, Kate, B and Dey, CS. Altered PPARγ expression inhibits myogenic differentiation in C2C12 skeletal muscle cells. Mol. Cell. Biochem. 2007, 294, 163.
Panchagnula, R, Bindra, P, Pillai, O, Kumar, N and Dey, CS. Stability of insulin under iontophoretic conditions. Pharmazie. 2006, 61, 1014.
Khurana, A and Dey, CS. Involvement of c-jun n-terminal kinase activities in skeletal muscle differentiation. J. Muscle Res. Cell Motil. 2004, 25, 645.
Verma, NK, Singh, J and Dey, CS. PPAR-γ expression modulates insulin sensitivity in C2C12 skeletal muscle cells. Brit. J. Pharmacol. 2004, 143, 1006.
Miranda, ER and Dey, CS. Effect of chromium and zinc on insulin signaling in skeletal muscle. Biol. Trace Elemt. Res. 2004, 101,19.
Kumar, N, Kaul, CL. Ishrath, A and Dey, CS. Combination of metformin and thiazolidindiones restore insulin signalling in insulin-resistant cultured myotubes. Life Sci. 2004, 74, 1877.
Kumar, N and Dey, CS. Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones. Mol. Cell. Biochem. 2004, 260, 55.
Pillai, O, Kumar, N, Dey, CS, Sivaprasad, SN and Panchagnula, R. Transdermal iontophoresis of insulin: III. Influence of electronic parameters. Meth. Find. Exptl. Clin. Pharacol. 2004, 26, 399.
Pillai, O, Kumar, N, Dey, CS, Borkute, S, Nagalingam, S & Panchagnula, R: Transdermal iontophoresis of insulin. Part 1: A Study on the issues associated with the use of platinum electrodes on rat skin. J. Pharm. Pharmacol. 2003, 55, 1505.
Kumar, N and Dey, CS. Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells. Biochem. Pharmacol. 2003, 65, 249.
Khurana, AK and Dey, CS. p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiation. Differentiation. 2003, 71, 42.
Gargi, A, Kumar, N and Dey, CS. Differential regulation of MAP kinase isoforms by H2O2 in neuronal cells. Neuro. Res. Comm. 2003, 33, 17.
Kumar, N and Dey, CS. Metformin enhances insulin signaling in insulin –dependent and –independent pathways in insulin resistant muscle cells. Brit. J. Pharmacol, 2002, 137, 329.
Kumar, N and Dey, CS. Gliclazide increases IR tyrosine phosphorylation but not p38 activation in insulin-resistant myotubes. J. Exptl. Biol. 2002, 205, 3739.
Goel, HL and Dey, CS. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidyl inositol 3-kinase and extracellular signal regulated kinase. J. Cell. Physiol. 2002, 193, 187.
Goel, HL and Dey, CS. Role of protein kinase C during insulin mediated skeletal muscle cell spreading. J. Muscle Res. Cell Motil. 2002, 23, 269.
Goel, HL and Dey, CS. PKC regulated myogenesis is associated with activation of FAK, Cas, paxillin and formation of Cas-Crk complex leading to JNK activation. Differentiation. 2002, 70, 257.
Goel, HL and Dey, CS. Focal adhesion kinase tyrosine phosphorylation is associated with myogenesis and modulated by insulin. Cell Prolif. 2002, 35,13.
Khurana, AK and Dey, CS. Involvement of Elk-1 transcription factor in L6E9 skeletal muscle differentiation. FEBS Lett. 2002, 527, 119.
Khurana, AK and Dey, CS. Subtype specific roles of mitogen activated protein kinases in L6E9 rat skeletal muscle cell differentiation. Mol. Cell. Biochem. 2002, 238, 27.
Ishrath, A, Kumar, N and Dey, CS. Differential activation of ERK and JNK by arsenite in mouse muscle cells. Comp. Biochem. Physiol. 2002, 132, 375.
Goel, HL and Dey, CS. Insulin mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C- terminal src kinase during skeletal muscle differentiation. Cell Biol. Int. 2002, 26, 557.
Kumar, N and Dey, CS. Skeletal cell model to screen anti-diabetic compounds. Accepted for grant of patent issue by the USPTO (2006) App. No. 09/984018(US), Patent No. 7052910 B2(US)/2006.
signal transduction and sperm motility
Gopalakrishnan, A, Dey, CS, Totey, SM, Pawshe, CH, Salunke,D, and Shaha, C. A testicular protein important for fertility has glutathione-S-transferase activity and is localised extracellularly in the seminiferous tubule. J. Biol. Chem. 1995, 270, 15675.
Dey, CS, and Brokaw, CJ. Activation of Ciona sperm motility: Phosphorylation of dynein polypetides and effects of inhibition of tyrosine kinase activity. J. Cell Sci. 1991, 100, 815.
Haldar, S, Dey, CS, and Majumder, GC. A ficoll gradient method for isolation of immature spermatozoa of high purity and intactness from goat caput epididymis. Arch. Androl. 1990, 24, 125.
Dey, CS, and Majumder, GC. Maturation specific type II cAMP-dependent protein kinase in goat sperm plasma membrane. Biochem. Int. 1990, 21 656.
Dey, CS, and Majumder, GC. Type I and Type II cAMP-dependent protein kinase in goat epididymal spermatozoa and their enriched activities in forward motile supermatozoa. Biochem. Cell Biol. 1990, 68, 459.
Dey, CS, and Majumder, GC. A simple qunatitative method of estimation of cell intactness based on ethidium bromide fluorescence. Biochem. Int. 1988, 17, 2, 367.
Majumder, GC, Haldar, S, Dey, CS, Barua, M and N. Roy. Occurrence of several ecto-proteins on goat spermatozoal surface that may regulate flagellar motility. Ind. J. Biochem. Biophys. 1988, 25, 215.
Dey, CS, and Majumder, GC. Phosphatidyl inositol inhibition of a sperm cyclic AMP-independent protein kinase. Biochem. Biophys. Res. Commun.1987, 146:,422.
Dey, CS, and Majumder, GC. Ecto-cyclic AMP receptor in goat epididymal spermatozoa and its change in activity during forward motility. J. Cell. Biochem. 1987, 35, 259.
Haldar, S, Dey, CS, and Majumder, GC. An ecto-cyclic AMP-independent protein kinase on goat supermatozoa and its change of activity during forward motility. Biochem. Int. 1986, 13, 809.
signal transduction and leishmania
Mukhopadhyay, A. G., & Dey, C. S. Effect of inhibition of axonemal dynein ATPases on the regulation of flagellar and ciliary waveforms in Leishmania parasites. Mol. Biochemi. Parasitol 2018, 225,27-37.
Reddy GS, Mukhopadhyay AG, Dey CS: The p38 MAP kinase inhibitor, PD 169316, inhibits flagellar motility in Leishmania donovani. Biochem. Biophys. Res. Comm. 2017, 493,1425.
Mukhopadhyay AG and Dey CS: Role of calmodulin and calcineurin in regulating flagellar motility and wave polarity in Leishmania. Parasitol. Res. 2017, 116, 3221.
Reddy GS, Mukhopadhyay AG and Dey CS: Characterization of ciliobrevin A mediated dynein ATPase inhibition on flagellar motility of Leishmania donovani. Mol Biochem. Parasitol. 2017, 214, 75.
Mukhopadhyay AG and Dey CS: Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform. Sci. Rep. 2016, 6:37308.
Mukhopadhyay AG and Dey CS: Two-headed outer- and inner-arm dyneins of Leishmania sp bear conserved IQ-like motifs. Biochem Biophys Rep. 2015, 4, 283.
Kaur A, Singh R, Dey CS, Sharma, SS, Bhutani, KK, Singh, IP: Antileishmanial phenyl propanoids from Alpinia galangal (Linn.) Willd. Ind. J. Exp. Biol. 2010, 48, 314.
Sharma S, Singh GM, Chavan HD and Dey CS: Proteomic analysis of wild type and arsenite resistant Leishmania donovani. Exptl. Parasitol. 2009, 123, 369.
Singh GM, Thakur M, Chakraborti PK and Dey CS: Evidence for the presence of R250G mutation at the ATPase domain of Topoisomerase II in an arsenite-resistant L. donovani that exhibits differential drug inhibition profile. Int. J. Antimicrob. Agents. 2009, 33, 80.
Singh GM , Chavan HD and Dey CS: Proteomic analysis of miltefosine resistant Leishmania reveals the possible involvement of eukaryotic initiation factor 4A, eIF4A. Int. J. Antimicrob. Agents. 2008, 31, 581.
Badiwala, HS, Singh G, Singh, R, Dey CS, Sharma, SS, Bhutani, KK and Singh IP: Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. J. Nat. Med. 2007, 61, 418.
Singh, G, and Dey CS. Induction of apoptosis-like cell death by pentamidine and doxorubicin through differential inhibition of topoisomerase II in arsenite-resistant L. donovani. Acta Tropica. 2007, 103, 172.
Chavan, HD, Singh, G and Dey CS. Confocal microscopic investigation of tubulin distribution and effect of paclitaxel on post-translationally modified tubulins in sodium arsenite resistant Leishmania donovani. Exptl. Parasitol. 2007, 116, 320.
Verma, NK, Singh, G and Dey, CS. Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exptl. Parasitol. 2006, 116, 1
Verma, NK and Dey, CS. Anti-leishmanial drug miltefosine causes insulin resistance in skeletal muscle cells in vitro. Diabetologia. 2006, 49,1656.
Jayanarayan, KG and Dey, CS. Altered tubulin dynamics, localization and post-translational modifications in sodium arsenite resistant Leishmania donovani in response to paclitaxel, trifluralin treatment and a combination of both and induction of apoptosis-like cell death. Parasitology. 2005, 131, 215.
Singh, G, Jayanarayan, KG and Dey, CS. Novobiocin induces apoptosis-like cell death in topoisomerase II over-expressing arsenite resistant Leishmania donovani. Mol. Biochem. Parasitol. 2005, 141, 57.
Verma, NK and Dey, CS. Possible mechanism of miltefosine mediated death of Leishmania donovani. Antimicrob. Agents Chemother. 2004, 48, 3010.
Jayanarayan, KG and Dey, CS. Altered expression, polymerization and cellular distribution of α/β-tubulins and apoptotic-like cell death in arsenite resistant Leishmania donovani promastigotes. Int. J. Parasitol. 2004, 34, 915.
Jayanarayan KG and Dey, CS. Overexpression and increased DNA topoisomerase like enzyme activity in arsenite resistant Leishmania donovani. Microbiol. Res. 2003, 158, 55.
Jayanarayan, KG and Dey, CS: Resistance to arsenite modulates expression of β- and γ-tubulin and sensitivity to paclitaxel during differentiation of Leishmania donovani. Parasitol. Res. 2002, 88, 754.
Kaur, J and Dey, CS. Putative P-glycoprotein expression in arsenite resistant Leishmania donovani down-regulated by verapamil. Biochem. Biophys. Res. Commun. 2000, 271, 615.
Prasad, V, Kumar, SS and Dey, CS. Resistance to arsenite modulates levels of α-tubulin and sensitivity to Paclitaxel in Leishmania donovani. Parasitol. Res. 2000, 86, 838.
Prasad, V and Dey, CS. Tubulin is hyperphosphorylated on serine and tyrosine residues in arsenite resistant Leishmania donovani. Parasitol. Res. 2000, 86, 876.
Prasad, V, Kaur, J and Dey, CS. Arsenite resistant Leishmania donovani promastigotes express an enhanced membrane P-type ATPase activity sensitive to verapamil treatment. Parasitol. Res. 2000, 86, 661.
other research area
Nemmani, KVS, Jena, GB, Dey, CS, Kaul, CL and RamaRao, P. Cell proliferation and natural killer cell activity by polyherbal formulation, Immu-21 in mice. Ind. J. Exptl. Biol. 2002, 40, 282.
Singh DD, Dey CS and Bhutani, KK. Down regulation of p34cdc2 by an aqueous fraction of Withania somnifera. Phytomed. 2001, 8, 492.
Dey, CS, Deitiker, PR and Epstein, HF. Assembly-dependent phosphorylation of myosin and paramyosin of native thick filaments in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 1992, 186, 1528.
Verma NK and Dey, CS : RNAi-mediated gene silencing: mechanisms and its therapeutic applications. J. Clin. Pharm. Therap. 2004, 29, 395.
Verma, MVS, Ashokrai, Y, Dey, CS and Panchagnula, R: P-glycoprotein inhibitors and their screening: a perspective from bioavailaility enhancement. Pharm. Res. 2003, 48, 347.
Jayanarayan, KG and Dey, CS. Microtubules: Dynamics, drug interaction and drug resistance in Leishmania. J. Clin. Pharm. Therap. 2002, 27, 313.
Kaul, CL and Dey, CS: Future drug discovery-new techniques, new targets. World Market Research Centre; Business Briefing : Future Drug Discovery. 2002, 44.
Panchagnula, R and Dey, CS : Monoclonal antibodies in drug targeting. J. Clin. Pharm. Therap. 1997, 22, 7.
Majumder, GC, Dey, CS, Haldar, S and Barua, M : Biochemical parameters of initiation and regulation of sperm motility. Arch. Androl. 1990, 24, 287.
C. S. Dey and N. Kumar: Development of insulin resistance in cultured skeletal muscle cells and reversal by thiazolidineldione. Non-alcoholic fatty liver disease (NAFLD) 10th Annual Symposium, Ranbaxy Science Foundation.2004
G. Singh, K.G. Jayanarayan and C. S. Dey: Arsenite Resistance in Leishmania and Possible Drug Targets. Online at Eurekah.com, December, 2006 and in the book “Drug Targets in Kinetoplastid Parasites” in the Advances in Experimental Medicine and Biology, Edt: Dr. H.K.Majumder, Landes Bioscience, Vol. 625, page 1, 2007.
G.C. Majumder, S. Saha, K. Das, D. Nath, A. Maiti, S. Dey, D. Roy, C. S. Dey, S. Mitra, A. Rana, J. Chakrabarty, S. Das, A. Bhoumik, S. Banerjee, M. Mandal, B. S. Jaiswal, P. Ghosh, A. Das, D. Bhattacharyya and S. R. Dungdung: Role of Sperm Surface Molecules in Motility Regulation. Mammalian Endocrinology and Male Reproductive Biology, Chapter 8, Edt. S. K. Singh. CRC Press, 197-243.2015, ebook isbn: 978-1-4987-2736-5.
D. Mishra, C. S. Dey. Protein Kinase C (PKC) Negatively Regulate Neuronal Insulin Signaling in vitro, Diabetes, 79th Scientific Sessions American Diabetes Association, San Francisco, 2019, p. 1787.
Y. Yadav, C. S. Dey. Ser/Thr Phosphatase-PP2C Negatively Regulates AS160 and GSK3β Activity in Neuronal Insulin Signal Transduction Pathway, Diabetes, 79th Scientific Sessions American Diabetes Association, San Francisco, 2019, p. 1789.
Y. Yadav, C. S. Dey. Serine/Threonine Phosphatase PP2C- A Possible Positive Regulator of Neuronal Insulin Resistance in vitro, 7th Helmholtz Diabetes Conference, Munich, 2019.
M. Sharma, C. S. Dey. Akt2 is Required for Glucose Uptake in Neuronal Insulin Signaling in vitro, Diabetes, 79th Scientific Sessions American Diabetes Association, San Francisco, 2019, p. 1790.
C. S. Dey and Mukhopadhyay A. G. Inhibition of axonemal dynein ATPases reveals heterogeneity in dyneins that regulate ciliary and flagellar waveforms in Leishmania. EMBO Cilia, Copenhagen, Denmark. 2018.
A. G. Mukhopadhyay and C. S. Dey. Heterogeneity in dynein ATPases and regulation of flagellar and ciliary waveforms in Leishmania parasites. International Workshop Dynein, Japan. 2017.
A. G. Mukhopadhyay and C. S. Dey. Calmodulin and calcineurin regulateflagellar motility in Leishmania. 28th Molecular Parasitology Meeting, Woods Hole, Massachusetts, USA. 2017.
A. G. Mukhopadhyay and C. S. Dey. cAMP mediated flagellar wave reversal in a detergent-extracted ATP-reactivated model of Leishmania parasites. EMBO Cilia, Amsterdam, The Netherlands. 2016.
A. G. Mukhopadhyay and C. S. Dey. A detergent-extracted model for studying flagellar motility in eukaryotic human parasites like Leishmania spp. 8th Bangalore Microscopy Course, National Centre for Biological Sciences (NCBS) Bangalore, India 2016.
C. S. Dey and A. G. Mukhopadhyay. Two-headed outer-and inner-arm dyneins of Leishmania sp bear conserved IQ-like motifs. BioMicroWorld, Barcelona, Spain. 2015.
A. G. Mukhopadhyay and C. S. Dey. Regulation of leishmanial flagellar motility. Bioworld 2014: Protein Structure and Function, New Delhi, India. 2014.
A. Chaudhary and C. S. Dey: Effects of modulators of nuclear receptor Rev-erbon insulin signaling pathway in differentiated C2C12 myotubes. Diabetes UK Professional Conference, 11-13- March, 2015. London UK and published in the abstract form in Diabetic Medicine, 32 (Suppl. 1), 2015.
P. Varshney, K.V.L. Parsa, C.S. Dey, MicroRNA regulation of insulin resistance in skeletal muscle, presented at the “Bioworld conference 2012, IIT-Delhi, India”.
P. Varshney, C.S. Dey, P21-activated kinase 2 (PAK2) negatively regulates neuronal glucose uptake and insulin sensitivity, presented at the Diabetes UK Professional Conference 2015, London, UK and published in the abstract form in Diabetic Medicine, 32 (Suppl. 1), 2015.
P. Varshney, C.S. Dey, Resveratrol, a potential anti-diabetic drug regulates neuronal insulin signaling and insulin resistant diabetes via P21-activated kinase 2 (PAK2), accepted at the BioPharma Asia Convention 2017, Singapore.
C.S.Dey and A. Arora: Downregulation of sirtuin 2 (SIRT2) protects neuronal cells from hyperinsulinemia mediated insulin resistance. Diabetes UK Professional Conference, 11-13- March, 2015. London UK and published in the abstract form in Diabetic Medicine, 32 (Suppl. 1), 2015.