Prof. Chinmoy Sankar Dey

Bhatnagar Awardee

J.C.Bose Fellow

Fellow of the Indian National Academy of Sciences,

Fellow of the National Academy of Sciences

Visiting Scientist, Diabetes Research Foundation, Madras

Adjunct Faculty, Institute of Life Sciences, Hyderabad,

Professor, Kusuma School of Biological Sciences

Indian Institute of Technology Delhi,

Hauz Khas, New Delhi 110016, India.

Email: csdey@bioschool.iitd.ac.in

Dr. Chinmoy Sankar Dey has done his Ph.D. from the Indian Institute of Chemical Biology, Kolkata. He did his Postdoctoral Research at the California Institute of Technology, USA, and the Baylor College of Medicine, Texas, USA. In 1994 he joined the National Institute of Pharmaceutical Education and Research (NIPER), Punjab, as an Assistant Professor and during the year 2000 he became the Professor and later became the Head of the Department of Biotechnology, NIPER, and worked upto the year 2010. Currently he is working as a Professor, in the School of Biological Sciences, at IIT-Delhi. He has over 70 primary research publications and 6 reviews in reputed international journals. He has one US patent, 3 book chapters. He has 20 years of teaching graduate and postgraduate students. He has guided several PhD and masters thesis. Because of his significant contributions in science Professor Dey has been awarded: (1) Shanti Swarup Bhatnagar Award, the highest award in science in India, in 2003 from the Prime Minster of India, Dr. Manmohan Singh, (2) National BioScience Award-2003 from the Department of Biotechnology, India, from Dr. R. Chidambaram, the then Scientific Advisor of  the Prime Minister of India, (3) OPPI award-2005 in “Pharmaceutical Biotechnology” by Hon'ble Minister Shri Kapil Sibal, (4) CDRI Award for Excellence in Drug Research-2008, (5) The prestigious J.C. Bose Fellowship from the Department of Science and Technology, 2009. He is a Visiting Scientist, at the Diabetes Research Foundation, Madras, and an Adjunct Professor of the Institute of Life Sciences, Hyderabad. Prof. Dey was a Member, Editorial Board of the journal Scientific Reports, (Nature Publishing group). He was a Regional Associate Editor, Journal of Biopharmaceutics and Biotechnology, USA. He was a Member, Editorial Board, Open Parasitology Journal, Bentham Publisher.

 
Research Interests

Diabetes Signalling Regulated by Signal Transduction

 Leishmania Flagellar Motility Regulated by Signal Transduction

Mouse skeletal muscle cells in culture.                                                  

A mouse neuroblastoma cells under bright field microscopy.

A magnified image of a muscle fibre.

Mouse neuroblastoma cells transfected with CRISPR plasmid having GFP as a reporter gene.

During last two and a half decades our research interests have been to understand how protein kinases and phosphatases  mediated signal transduction regulate the molecular mechanism of insulin resistant diabetes. Our laboratory has contributed in deciphering the complex signal transduction cascades to elucidate the mechanism of regulation of insulin resistance in skeletal muscle cells and neuronal cells in vitro. Major highlights are:

1. A novel in vitro insulin resistant neuronal cell model developed to study insights into the signalling mechanisms in neuronal insulin resistance. The model is simple, relevant, cheaper than animal models and good for primary screening.

2. Our laboratory has provided one of the possible mechanisms of action of Metformin, the FDA approved drug for the treatment of insulin resistance, against peripheral insulin resistant diabetes.

3.Our laboratory has identified proteins like PTEN (a protein phosphatase), FAK (a protein kinase), Sirt2 (a deacetylase), and PAK (a protein kinase) and their regulatory roles in insulin-sensitive and –resistant signaling pathways in skeletal muscle and neuronal cells in vitro. These provides opportunities for future animal/clinical studies for drug discovery. Currently we are looking deeper into the interactions and functions of very critical insulin signalling proteins Akt, AS160, protein kinase C in regulating insulin resistant diabetes.

A                                                                 B                                                  
C                                                                  D                                                

Effect of Paclitaxel on distribution of acetylated tubulins in Ld-Wt. (A) & (C) immunofluorescence images; (B) & (D) surface plot analysis of acetylated tubulins in control and taxol treated Ld-Wt respectively. Scale bars, 2mM.

Leishmaniasis causes a geographically widespread diseases, called Leishmanasis. The Leishmania flagellum is a highly versatile organelle that exhibits intricate environment triggered responses. However, till date flagellar motility and its regulation in Leishmania remains poorly understood despite the importance in its survival and infectivity. In humans, defects in cilia cause a group of severe diseases called ciliopathies. Eukaryotic parasites like trypanosomes have served as attractive models for the study of such genetic defects in humans. However, there is no suitable model till date for the study of the signalling and regulatory mechanisms of ciliary motility in ciliopathies. In our laboratory, we have developed a demembranated ATP-reactivated model (LRP) for studying molecular mechanisms that regulate flagellar motility in Leishmania. Such a model allows the researcher complete control to manipulate the cell chemically and mechanically under controlled standardized conditions. We believe that reactivation of flagellar motility in demembranated Leishmania presents it as an attractive model for flagellar motility studies. Using our model we observed that cAMP, via protein kinase A mediates “wave reversal” of the flagellar waveform to a ciliary waveform which has been believed to have a role in tactic responses such as obstacle-avoidance, chemotaxis, osmotaxis etc. With this model we are also interested in elucidating the effects of other second messenger molecules, role of dynein ATPases in regulating the flagellar beat and waveform.

 

Lab Members

Dr. Kapil Manglani

Current work- Protein kinases in insulin signalling

Qualifications- PhD from NII, New Delhi

 

MEdha sharma

Current work- Protein kinases in insulin signalling

Qualifications- CSIR-SRF,  B.Tech and M.Tech Biotechnology, GBU

Devanshi mishra

Current work- Protein kinases in insulin signalling

Qualifications- CSIR-SRF, B.Tech Biotechnology,GGSIPU

yamini

Current work- Protein phosphatases in insulin signalling

Qualifications- DST-Inspire,  B.Tech and M.Tech Biotechnology, GBU

 

ALUMNI

Dr. amita arora

Worked on: SIRT 2 in regulating insulin sensitivity and resistant in neuronal and muscle cells.

Current Affiliation: University of Helsinki, Finland.

Dr. abhijeet K. Chaudhary

Worked on: NCor regulating insulin sensitivity in muscle cells.

Former SERB Young Scientist Fellow

Dr. AAkash G. mukhopadhyay

Worked on: Molecular regulation of Leishmania flagellar motility and waveforms.

Current Affiliation: Birkbeck Institute,University of London, UK.

Dr. Pallavi varshney

Worked on: PAK2 in regulating insulin sensitivity and resistant in neuronal and muscle cells.

Current Affiliation: University of Michigan, USA.

G. Srinivas reddy

Worked on: Effect of Ciliobrevin A on Leishmania flagellar motility.

Current Affiliation: CCMB, Hyderabad.

Former Masters Student.

 

Professor C.S.Dey

Kusuma School of Biological Sciences

Indian Institute of Technology Delhi,

Hauz Khas, New Delhi 110016, India.

Email: csdey@bioschool.iitd.ac.in

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